What is Dopamine?

5th August 2012

Dopamine is an important neurotransmitter molecule in the central nervous system enabling information flow between cells. Vital for the control and coordination of movement, dopamine is also involved in keeping us alert, active and motivated. It is necessary for “executive” functions such as constructive thinking, concentration and memory formation. Dopamine is also required for the generation of pleasurable feelings and sexual desire and it has a positive effect on the heart, circulation and metabolic rate. Scientific studies link low dopamine levels/function with:

  • anxiety and depression
  • cravings and addictions
  • fibromyalgia
  • obesity
  • Parkinson’s disease
  • Restless Legs Syndrome

Dopamine receptors

At least five different dopamine receptors (D1-D5) have been identified across the nervous system and it seems that the density and variety of receptors we each have vary considerably depending on our genetic tendency and our development in the womb and during childhood.

Dopamine levels and functioning reflect our individual receptor repertoire and are reduced by stress, lack of the right nutrients, ageing and certain medications. Additionally, from mid-life, dopamine levels start declining at a rate of approximately 13% each decade, which accounts for many of the general symptoms of ageing such as fatigue, poor sleep quality, reduced emotional activity, depression, reduced motor activity, loss of muscle tone and cognitive function etc.

In women, low dopamine levels in mid-life exacerbate the physiological and psychological effects of declining oestrogen, producing more severe hot flushes, night sweats, sleep disturbances and mood swings.

For men, the effects of falling testosterone such as; decreasing muscle mass, increasing body fat, reduced physical energy/endurance, gradually decreasing libido, loss of bone density, increasing cholesterol etc are all exacerbated by declining dopamine.

Emotionally, dopamine is required to generate:

  • feelings of pleasure
  • feelings of attachment and love
  • a sense of altruism (unselfish concern for the welfare of others)
  • integration of thoughts and feelings

and low dopamine may be associated with:

  • anhedonia (inability to feel pleasure)
  • difficulty in feeling love and sensing attachment to another
  • difficulty in accessing and expressing real feelings
  • a lack of remorse about actions
  • distractibility

Dopamine and depression

The adult brain is formed from our experiences in childhood and it has been shown that early social deprivation or stress can lead to permanent reduction in dopaminergic neurones especially in the prefrontal cortex of the brain where they are usually very dense, affecting the capacity for positive emotionality. An unsatisfactory early relationship between mother and child for example, results in fewer dopamine receptors and a constricted capacity for pleasure and reward in later life, increasing the propensity of depressive episodes.

The newer pharmacological teatments for depression are known as SSRIs (selective serotonin reuptake inhibitors). The basis for their use is that depression is caused by low serotonin levels n the brain. SSRIs work by inhibiting the reuptake of serotonin back into the nerve cell, thereby increasing the level existing at the synaptic cleft. However, this entire approach to treating depression is now in question and the drug companies promoting these SSRIs for years are now focussing their research efforts towards the wider role of dopamine.   

Improving dopamine levels/functioning

Conventional medicine treats tonditions associated with low dopamine levels/function with dopamine agonists – drugs that stimulate dopamine receptors. Unfortunately, in time, this constant and unnatural high level of stimulation desensitises the dopamine receptors so that drug effectiveness declines with time and drug dosages then need to be increased. This further desensitises the receptors (which are already in short supply) and increases negative side effects.

Improve dopamine levels naturally

Dopamine is made in the body from the amino acid tyrosine which is derived from the proteins we eat or from the amino acid phenylalanine. Unfortunately, eating more tyrosine-rich foods does not automatically confer higher dopamine levels.

However a proven way to improve dopamine levels is with phenylethylamine (PEA) (1).

PEA is a molecule we produce endogenously (made in the body) and which is known to have specific neuro-regenerating properties. We produce PEA when we feel happy, joyous and calm. People in love have particularly high levels (hence it has been coined the “love molecule”) as do long-distance runners – partly explaining the anti-depressant effect of exercise. 

Importantly, PEA also has the ability to raise the level of freely circulating dopamine in the brain.

Products containing significant quantities of PEA able to access the central nervous system to positively influence low or declining dopamine levels/function include: Klamath flakes, MEMaid, QuietLEGS, VitalCALM, VitalLIFT, VitalMAX and VitalWOMAN.

If you would like any further information on any of these products or to seek advice from our pharmacist, please call free on 07748312313 between 10-4pm, Monday-Friday.

References

1) Murata M., Katagiri N., Ishida K., et al., Effect of beta-phenylethylamine on extracellular concentrations of  dopamine in the nucleus accumbens and prefrontal cortex. Brain Research 2009 May t;1269:40-6

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3 Comments

  1. Mary Elizabeth Thomas
    2 June 2012 at 21:29 | Reply

    Istarted treatment for terrible restless legs with Ropinerole tablets. The side effects far outweighed any benefit I got. From the advice of a Consultant Neurologist I was put on Neupro (Rotigotine) transdermal patches. These have helped miraculously and for the first 5 months everything was great, but during the last two months I seem to have developed an allergic reaction to the patches which leave my skin very irritated and burning, with itching occuring on other parts of my body including arms, chest and tummy. Because of this my G.P. has asked me to try the Neurologists’ second advice, which is to gradually build up to strength 2mgs a day of Clonazepam. I am only on my second day at the moment and my legs are driving me crazy! I didn’t sleep a wink last night and have been going about like a zombie all day with my legs still driving me mad! I have read with interest about Vitacalm. How much evidence is there that these tablets can help really bad cases, as I am very nervous about trying anything I know nothing about. Can you please help.

  2. Nicola Benbow
    8 May 2012 at 17:56 | Reply

    Is it safe please to take VitalCalm with hypertensive tablets (Lisinopril 20mg and Indapamide 2.5mg) each one daily? I am experiencing restless legs at night together with tingling hands and feet. All blood tests normal! Would be so grateful for your advice. Thank you.

  3. Hasmukhlal Thobhani
    21 April 2012 at 17:17 | Reply

    I have gone through this, and I will try Vital Calm and see how good is for me. At present I have very bad RLS My GP has given me Ropinirole, start with onley 1/4 mg about 2007 but now gone up to 2mg or 3mg and this is going up an up

    As you have said above has also happen in my childhood and same is at present, so I hope Vital Calm will halp me

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